Chemistry Background of Pharmaceutical Intermediates
Pharmaceutical intermediates are the chemicals produced during the multistep synthesis of active pharmaceutical ingredients (APIs). They are chemically synthesised compounds that act as substrates or reagents for the production of drug molecules. The chemistry employed in producing it includes organic transformations like alkylation, acylation, oxidation, reduction, etc. These intermediates undergo further reactions to yield the desired API. Maintaining the structural integrity and purity of intermediates is crucial as any impurities carried forward can affect the therapeutic efficacy and safety of drugs.
Indian Dominance and Growing Export
India has emerged as a dominant global supplier of Pharmaceutical Intermediates accounting for nearly 30% of world exports. Low labor costs, skilled workforce, and a large pool of experienced chemists have enabled Indian companies to establish robust capabilities in intermediate synthesis. Major pharma giants in India partner with contract manufacturers for outsourcing their intermediate needs. The industry has also witnessed rapid consolidation with the emergence of large integrated manufacturers. Intermediates exports from India have grown steadily over the years with the USA, Europe, China, and Japan serving as key markets. Indian players are ramping up capacities and quality certifications to capture a larger share of regulated international markets.
Growth in Generics and Emerging
The generics drug market has been a significant demand driver for pharmaceutical intermediates globally. As patent protections expire, many blockbuster drugs are facing competition from low-cost generic versions. This has translated to increased need for generic drug intermediates. Emerging markets like China, Brazil, Eastern Europe, Africa, and the Middle East offer immense prospects through their rising healthcare spends and growing generics consumption. Indian intermediates suppliers have proactively expanded into these regions to benefit from robust future growth. Contract manufacturing hubs catering to generics firms are also increasing investments to capture outsourcing opportunities.
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